Nunes-Carneiro Diogo, Marques-Pinto Andre, Cavadas Vítor, Fraga Avelino
Urology Department, Centro Hospitalar do Porto, Porto, Portugal.
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
BMJ Case Rep. 2018 Nov 1;2018:bcr-2018-226316. doi: 10.1136/bcr-2018-226316.
Adult granulosa cell tumours are extremely rare and usually benign but sometimes can assume an aggressive behaviour. A 31-year-old man presented with a 45 mm testicular mass. Radical orchiectomy was performed. Histological examination showed elongated cells, with hyperchromatic nuclei and Call-Exner bodies. Immunohistochemical analysis revealed positivity to vimentin, inhibin and negative PLAP and AE1/AE3 staining. The patient did not receive any adjuvant therapy and remained asymptomatic during 10 years. There are few cases of adult granulosa cell tumours and there is no consensus regarding malignancy criteria, treatment and follow-up. The description of these entities is crucial to allow a better management of these patients.
成人颗粒细胞瘤极为罕见,通常为良性,但有时也会表现出侵袭性。一名31岁男性患者出现一个45毫米的睾丸肿块。进行了根治性睾丸切除术。组织学检查显示细胞呈细长形,核染色质增多,并可见Call-Exner小体。免疫组化分析显示波形蛋白、抑制素呈阳性,胎盘碱性磷酸酶(PLAP)和细胞角蛋白AE1/AE3染色呈阴性。该患者未接受任何辅助治疗,在10年期间一直无症状。成人颗粒细胞瘤病例很少,关于恶性标准、治疗和随访尚无共识。对这些实体的描述对于更好地管理这些患者至关重要。