外用阿维A治疗离心性边缘性角化棘皮瘤病例
Case of keratoacanthoma centrifugum marginatum treated with acitretin.
作者信息
Mehrtens Sarah Helen, de la Hera Inma, Shankar Sonal
机构信息
Department of Dermatology, Medway NHS Foundation Trust, Gillingham, UK.
出版信息
BMJ Case Rep. 2018 Nov 1;2018:bcr-2018-226818. doi: 10.1136/bcr-2018-226818.
Abstract
Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma (KA), characterised by a progressively expanding tumour with a lack of spontaneous remission and significant scarring. KCM has been reported previously in less than 50 cases worldwide. We present the case of a large solitary KCM on the right shin of a 71-year-old woman. This was treated successfully with oral acitretin for 16 months with sustained remission at 24 months. Our case provides further supporting evidence for acitretin as a useful treatment for KCM to induce remission, prevent extensive surgery and minimise destructive scarring.
摘要
离心性边缘性角化棘皮瘤（KCM）是角化棘皮瘤（KA）的一种罕见变体，其特征是肿瘤逐渐扩大，缺乏自发缓解且有明显瘢痕形成。此前全球报道的KCM病例不足50例。我们报告了一名71岁女性右小腿出现的一个巨大孤立性KCM病例。该病例口服阿维A治疗16个月，24个月时持续缓解，治疗成功。我们的病例为阿维A作为治疗KCM以诱导缓解、避免广泛手术并使破坏性瘢痕最小化的有效治疗方法提供了进一步的支持证据。
相似文献
1
Case of keratoacanthoma centrifugum marginatum treated with acitretin.外用阿维A治疗离心性边缘性角化棘皮瘤病例
BMJ Case Rep. 2018 Nov 1;2018:bcr-2018-226818. doi: 10.1136/bcr-2018-226818.
2
A case of Ferguson-Smith type multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum: response to oral acitretin.1例与离心性边缘性角化棘皮瘤相关的弗格森-史密斯型多发性角化棘皮瘤：对口服阿维A的反应
Clin Exp Dermatol. 2007 Nov;32(6):683-6. doi: 10.1111/j.1365-2230.2007.02498.x. Epub 2007 Aug 22.
3
Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin-A case report and review of the literature.离心性边缘性角化棘皮瘤与机械性创伤相关：阿维A治疗反应 - 病例报告及文献复习
Dermatol Ther. 2020 May;33(3):e13397. doi: 10.1111/dth.13397. Epub 2020 May 5.
4
Keratoacanthoma centrifugum marginatum after photodynamic therapy with good response to oral retinoids and topical 5-fluorouracil.光动力疗法治疗后边缘离心性角层棘皮瘤对口服维甲酸和 5-氟尿嘧啶具有良好的反应。
Dermatol Ther. 2019 Jul;32(4):e12988. doi: 10.1111/dth.12988. Epub 2019 Jun 21.
5
Keratoacanthoma Centrifugum Marginatum: Response to Acitretin.离心性边缘性角化棘皮瘤：对阿维A的反应
Skinmed. 2017 Feb 1;15(1):69-71. eCollection 2017.
6
A case of multiple keratoacanthoma centrifugum marginatum: response to oral etretinate.一例多发性离心性边缘性角化棘皮瘤：对口服阿维A的反应。
J Am Acad Dermatol. 2003 Feb;48(2):282-5. doi: 10.1067/mjd.2003.66.
7
Multiple keratoacanthoma and oral lichen planus successfully treated with systemic retinoids and review of multiple keratoacanthoma associated with lichen planus.
Int J Dermatol. 2018 Sep;57(9):1125-1127. doi: 10.1111/ijd.13974. Epub 2018 Mar 25.
8
Acitretin induces remission in generalized eruptive keratoacanthoma of Grzybowski.阿维A可诱导Grzybowski型泛发性 eruptive 角化棘皮瘤缓解。 （注：“eruptive”可能是“爆发性的”之类意思，这里直接保留英文更准确，因为不清楚准确对应的中文专业术语）
Int J Dermatol. 2015 Feb;54(2):e67-9. doi: 10.1111/ijd.12700.
9
Keratoacanthoma centrifugum marginatum: a rare atypical variant of keratoacanthoma.
Clin Exp Dermatol. 2008 May;33(3):259-61. doi: 10.1111/j.1365-2230.2007.02609.x. Epub 2007 Dec 10.
10
Unusual association between acrokeratosis verruciformis of Hopf and multiple keratoacanthomas. Successful therapy with acitretin.霍普夫疣状肢端角化病与多发性角化棘皮瘤之间的罕见关联。阿维A治疗成功。
J Dtsch Dermatol Ges. 2004 Jun;2(6):440-2. doi: 10.1046/j.1439-0353.2004.04776.x.
引用本文的文献
1
Keratoacanthoma Centrifugum Marginatum - A Tumour in Disguise.离心性边缘性角化棘皮瘤——一种伪装的肿瘤。
Indian J Dermatol. 2024 Jan-Feb;69(1):87-89. doi: 10.4103/ijd.ijd_215_23. Epub 2024 Feb 27.
2
Surgical excision of a giant solitary keratoacanthoma in the cheek: a case report and literature review.颊部巨大孤立性角化棘皮瘤的手术切除：一例报告并文献复习
AME Case Rep. 2023 Dec 1;8:7. doi: 10.21037/acr-23-100. eCollection 2024.
3
Granuloma Annulare Mimicking Squamous Cell Carcinoma.模仿鳞状细胞癌的环状肉芽肿。
Cureus. 2022 Jul 27;14(7):e27372. doi: 10.7759/cureus.27372. eCollection 2022 Jul.
本文引用的文献
1
Keratoacanthoma Centrifugum Marginatum: Response to Acitretin.离心性边缘性角化棘皮瘤：对阿维A的反应
Skinmed. 2017 Feb 1;15(1):69-71. eCollection 2017.
2
Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge.离心性边缘性角化棘皮瘤：一项诊断与治疗挑战。
JAAD Case Rep. 2016 May 25;2(3):206-8. doi: 10.1016/j.jdcr.2016.03.010. eCollection 2016 May.
3
A giant mass on the left shin: report of a case.左小腿巨大肿物：1例报告
Int J Clin Exp Pathol. 2015 Feb 1;8(2):2180-2. eCollection 2015.
4
Keratoacanthoma centrifugum marginatum: unresponsive to oral retinoid and successfully treated with wide local excision.离心性边缘性角化棘皮瘤：对口服维甲酸无反应，经广泛局部切除成功治疗。
Dermatol Reports. 2010 Jan 18;2(1):e1. doi: 10.4081/dr.2010.e1.
5
Spontaneous resolution of keratoacanthoma centrifugum marginatum.
Clin Exp Dermatol. 2014 Oct;39(7):854-6. doi: 10.1111/ced.12435.
6
Successful treatment of keratoacanthoma centrifugum marginatum with local application of imiquimod cream.咪喹莫特乳膏局部应用成功治疗离心性边缘性角化棘皮瘤。
Int J Dermatol. 2007 Dec;46(12):1321-2. doi: 10.1111/j.1365-4632.2007.03397.x.
7
A case of Ferguson-Smith type multiple keratoacanthomas associated with keratoacanthoma centrifugum marginatum: response to oral acitretin.1例与离心性边缘性角化棘皮瘤相关的弗格森-史密斯型多发性角化棘皮瘤：对口服阿维A的反应
Clin Exp Dermatol. 2007 Nov;32(6):683-6. doi: 10.1111/j.1365-2230.2007.02498.x. Epub 2007 Aug 22.
8
Keratoacanthoma centrifugum marginatum: a diagnostic and therapeutic challenge.离心性边缘性角化棘皮瘤：诊断与治疗挑战
Cutis. 2004 Apr;73(4):257-62.
9
[Multiple keratoacanthoma centrifugum marginatum].[多发性离心性边缘性角化棘皮瘤]
Ann Dermatol Venereol. 2002 Apr;129(4 Pt 1):413-5.
10
Brief review of keratoacanthomas and description of keratoacanthoma centrifugum marginatum, another variety of keratoacanthoma.
Aust J Dermatol. 1965 Dec;8(2):65-72. doi: 10.1111/j.1440-0960.1965.tb01715.x.
Zotero 插件