McIntyre I M, Norman T R, Marriott P F, Burrows G D
J Affect Disord. 1987 May-Jun;12(3):203-6. doi: 10.1016/0165-0327(87)90028-0.
The nocturnal synthesis of the pineal hormone melatonin was examined from 8 p.m. to midnight in 11 patients with panic disorder and eight control subjects. Patient concentrations of melatonin were significantly lower than controls at 10 p.m. (P less than 0.05; Kruskal-Wallis one-way ANOVA) and midnight (P less than 0.01). At 9 p.m. and 11 p.m., patient concentrations were also lower than controls, but were not statistically significantly different (P = 0.09). From these data, it is postulated that some patients with panic disorder exhibit a generalised defect in sensitivity of beta-adrenergic receptors or of sympathetic transmission.
在晚上8点至午夜期间，对11名惊恐障碍患者和8名对照受试者的褪黑素夜间合成情况进行了检查。在晚上10点（P<0.05；Kruskal-Wallis单因素方差分析）和午夜（P<0.01）时，患者的褪黑素浓度显著低于对照组。在晚上9点和11点时，患者的浓度也低于对照组，但差异无统计学意义（P=0.09）。根据这些数据推测，一些惊恐障碍患者存在β-肾上腺素能受体或交感神经传递敏感性的普遍缺陷。
