McIntyre I M, Judd F K, Burrows G D, Armstrong S M, Norman T R
Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
Am J Psychiatry. 1990 Apr;147(4):462-4. doi: 10.1176/ajp.147.4.462.
Nocturnal plasma melatonin concentrations were measured in seven patients with panic disorder and eight healthy control subjects. The five patients who had never received psychotropic medication had significantly greater melatonin concentrations from 4:00 a.m. to 7:00 a.m. than the control subjects. In addition it is possible that a phase delay occurred in these unmedicated patients. The findings are discussed in terms of previous studies showing increased melatonin in manic patients and the effect of intense stress on melatonin synthesis. The two patients who had been medication free for only 1 week showed a decreased melatonin rhythm, which is consistent with previous findings in medicated patients.
对7名恐慌症患者和8名健康对照者测量了夜间血浆褪黑素浓度。5名从未接受过精神药物治疗的患者在凌晨4点至7点的褪黑素浓度显著高于对照者。此外，这些未服药的患者可能出现了相位延迟。根据先前关于躁狂症患者褪黑素增加以及强烈应激对褪黑素合成影响的研究对这些发现进行了讨论。仅停药1周的两名患者显示褪黑素节律降低，这与先前对服药患者的研究结果一致。
