Tovell D R, Yacyshyn H P, Misra H K, Knaus E E, Wiebe L I, Samuel J, Gill M J, Tyrrell D L
J Med Virol. 1987 Jun;22(2):183-8. doi: 10.1002/jmv.1890220210.
Selective uptake of nucleoside analogues by herpes simplex virus infected cells may serve as the basis for a specific non-invasive diagnostic test for herpes simplex encephalitis. We have examined the effect of acyclovir on the selective uptake of [131I] 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in herpes simplex virus infected primary rabbit kidney cells. Infected cells treated with acyclovir continued to concentrate [131I] 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil for up to 24 h after the addition of the antiviral agent. These results indicated that therapy with acyclovir for as long as 24 h would not prevent the selective trapping of nucleoside analogues. This has important implications for the use of nucleoside analogues in diagnostic brain scans to detect herpes simplex encephalitis.
单纯疱疹病毒感染的细胞对核苷类似物的选择性摄取，可能成为单纯疱疹性脑炎特异性非侵入性诊断检测的基础。我们研究了阿昔洛韦对单纯疱疹病毒感染的原代兔肾细胞中[131I] 1-(2'-氟-2'-脱氧-β-D-阿拉伯呋喃糖基)-5-碘尿嘧啶选择性摄取的影响。用阿昔洛韦处理的感染细胞在加入抗病毒药物后长达24小时内持续浓缩[131I] 1-(2'-氟-2'-脱氧-β-D-阿拉伯呋喃糖基)-5-碘尿嘧啶。这些结果表明，长达24小时的阿昔洛韦治疗不会阻止核苷类似物的选择性捕获。这对于在诊断脑部扫描中使用核苷类似物检测单纯疱疹性脑炎具有重要意义。
