Hess C W, Ludin H P
J Neurol. 1987 Jun;234(5):298-302. doi: 10.1007/BF00314284.
Brain-stem auditory evoked potentials (BAEPs) to paired stimuli of various intervals were recorded using a subtraction technique to cancel the first and facilitate recognition of the second response. In a pilot series of 12 experiments, no latency change was encountered with paired click intervals (PCI) of 8 and 6 ms. Thirty healthy subjects were then investigated by presenting single and paired stimuli with a PCI of 4, 3.1, 2.3 and 1.5 ms at a repetition rate of 10/s to each subject. With diminishing PCIs, identification and latency measurement of waves IV and V became increasingly difficult because of marked amplitude reduction. Component III remained identifiable in all but two recordings and showed a statistically significant latency increase and amplitude reduction only when the stimuli were presented 1.5 ms apart. Component I did not show a consistent latency change with any PCI but its amplitude was significantly reduced with 4 ms PCI. These findings differ from those reported when using PCIs of 5 ms or more and when using single stimuli at a high repetition rate, where component V was the most stable. The alterations of evoked potentials found only with a PCI of 1.5 ms are probably of central origin.
采用减法技术记录不同间隔成对刺激的脑干听觉诱发电位（BAEPs），以消除第一个反应并便于识别第二个反应。在12次实验的预试验系列中，8毫秒和6毫秒的成对点击间隔（PCI）未出现潜伏期变化。然后对30名健康受试者进行研究，以10次/秒的重复率向每位受试者呈现PCI为4、3.1、2.3和1.5毫秒的单刺激和成对刺激。随着PCI减小，由于波幅显著降低，波IV和波V的识别及潜伏期测量变得越来越困难。除两份记录外，成分III在所有记录中均可识别，且仅在刺激间隔为1.5毫秒呈现时，显示出统计学上显著的潜伏期延长和波幅降低。成分I在任何PCI下均未表现出一致的潜伏期变化，但其波幅在PCI为4毫秒时显著降低。这些发现与使用5毫秒或更长PCI以及以高重复率使用单刺激时所报告的结果不同，在后一种情况下成分V最稳定。仅在PCI为1.5毫秒时发现的诱发电位改变可能源于中枢。
