肺部微生物组及其在肺炎中的作用。
The Lung Microbiome and Its Role in Pneumonia.
机构信息
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU Human Microbiome Program, New York University School of Medicine, New York, NY 10028, USA.
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU Human Microbiome Program, New York University School of Medicine, New York, NY 10028, USA.
出版信息
Clin Chest Med. 2018 Dec;39(4):677-689. doi: 10.1016/j.ccm.2018.07.003.
Abstract
The use of next-generation sequencing and multiomic analysis reveals new insights on the identity of microbes in the lower airways blurring the lines between commensals and pathogens. Microbes are not found in isolation; rather they form complex metacommunities where microbe-host and microbe-microbe interactions play important roles on the host susceptibility to pathogens. In addition, the lower airway microbiota exert significant effects on host immune tone. Thus, this review highlights the roles that microbes in the respiratory tract play in the development of pneumonia.
摘要
下一代测序和多组学分析的使用揭示了在下呼吸道微生物身份方面的新见解，模糊了共生菌和病原体之间的界限。微生物不是孤立存在的;相反，它们形成复杂的混合群落，其中微生物-宿主和微生物-微生物相互作用对宿主易感性病原体起着重要作用。此外，下呼吸道微生物群对宿主免疫状态产生重大影响。因此，本综述强调了呼吸道微生物在肺炎发展中的作用。
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Am J Infect Control. 2018 Jan;46(1):2-7. doi: 10.1016/j.ajic.2017.08.036. Epub 2017 Oct 16.
2
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Antimicrob Agents Chemother. 2017 Sep 22;61(10). doi: 10.1128/AAC.00954-17. Print 2017 Oct.
3
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J Med Virol. 2017 Dec;89(12):2098-2107. doi: 10.1002/jmv.24895. Epub 2017 Jul 25.
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Am J Respir Crit Care Med. 2017 Dec 15;196(12):1610-1612. doi: 10.1164/rccm.201703-0537LE.
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Bacterial Topography of the Healthy Human Lower Respiratory Tract.
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