MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils.
作者信息
Yang Qing, Yasuda Tomohiko, Choi Eunyoung, Toyoda Takeshi, Roland Joseph T, Uchida Eiji, Yoshida Hiroshi, Seto Yasuyuki, Goldenring James R, Nomura Sachiyo
机构信息
Institute of Pathogen Biology, School of Basic Medical Sciences, Shandong University, Jinan, China; Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee; Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Gastrointestinal Surgery, Graduate School, Nippon Medical School, Tokyo, Japan.
出版信息
Gastroenterology. 2019 Feb;156(3):577-581.e4. doi: 10.1053/j.gastro.2018.10.049. Epub 2018 Nov 2.
Abstract
摘要
相似文献
1
MEK Inhibitor Reverses Metaplasia and Allows Re-Emergence of Normal Lineages in Helicobacter pylori-Infected Gerbils.
Gastroenterology. 2019 Feb;156(3):577-581.e4. doi: 10.1053/j.gastro.2018.10.049. Epub 2018 Nov 2.
2
Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils.
Digestion. 2006;74(3-4):187-98. doi: 10.1159/000100503. Epub 2007 Mar 6.
3
Helicobacter pylori induces gastritis and intestinal metaplasia but no gastric adenocarcinoma in Mongolian gerbils.
Scand J Gastroenterol. 2005 Nov;40(11):1313-20. doi: 10.1080/00365520510023611.
4
5
Suppressive effect of rice extract on Helicobacter pylori infection in a Mongolian gerbil model.
J Gastroenterol. 2005 May;40(5):459-66. doi: 10.1007/s00535-005-1570-7.
6
Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori.
J Pathol. 2016 Aug;239(4):399-410. doi: 10.1002/path.4735. Epub 2016 Jun 22.
7
Induction of gastric ulcer and intestinal metaplasia in mongolian gerbils infected with Helicobacter pylori.
J Gastroenterol. 1996 Oct;31(5):755-7. doi: 10.1007/BF02347631.
8
Effect of chronic acid inhibition on duodenal bulb gastric metaplasia and Helicobacter pylori.
Ital J Gastroenterol Hepatol. 1998 Apr;30(2):235-6.
9
Helicobacter pylori infection and high dietary salt independently induce atrophic gastritis and intestinal metaplasia in commercially available outbred Mongolian gerbils.
Dig Dis Sci. 2003 Mar;48(3):475-85. doi: 10.1023/a:1022524313355.
10
Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori.
Lab Invest. 2007 Dec;87(12):1265-76. doi: 10.1038/labinvest.3700682.
引用本文的文献
1
H. Pylori-Facilitated TERT/Wnt/β-Catenin Triggers Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy.
Adv Sci (Weinh). 2025 Jan;12(3):e2401227. doi: 10.1002/advs.202401227. Epub 2024 Nov 25.
2
Role of spasmolytic polypeptide-expressing metaplasia in gastric mucosal diseases.
Am J Cancer Res. 2023 May 15;13(5):1667-1681. eCollection 2023.
3
Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.
Gastroenterology. 2022 Feb;162(2):415-430. doi: 10.1053/j.gastro.2021.10.036. Epub 2021 Oct 30.
4
Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa.
J Pathol. 2020 Jul;251(3):336-347. doi: 10.1002/path.5469. Epub 2020 Jun 15.
5
Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach.
Nat Commun. 2019 Dec 5;10(1):5549. doi: 10.1038/s41467-019-13479-6.
本文引用的文献
1
Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer.
N Engl J Med. 2018 Mar 22;378(12):1085-1095. doi: 10.1056/NEJMoa1708423.
2
Epidermal growth factor receptor inhibition downregulates -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis.
Gut. 2018 Jul;67(7):1247-1260. doi: 10.1136/gutjnl-2016-312888. Epub 2017 May 4.
3
Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report.
Gut. 2017 Jan;66(1):6-30. doi: 10.1136/gutjnl-2016-312288. Epub 2016 Oct 5.
4
Eradication of Helicobacter pylori and Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies.
J Natl Cancer Inst. 2016 Jul 14;108(9). doi: 10.1093/jnci/djw132. Print 2016 Sep.
5
Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori.
J Pathol. 2016 Aug;239(4):399-410. doi: 10.1002/path.4735. Epub 2016 Jun 22.
6
Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis.
Gastroenterology. 2016 May;150(5):1113-1124.e5. doi: 10.1053/j.gastro.2016.01.028. Epub 2016 Feb 2.
7
Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions.
Gastroenterology. 2016 Apr;150(4):918-30.e13. doi: 10.1053/j.gastro.2015.11.049. Epub 2015 Dec 8.
8
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.
Nat Med. 2015 May;21(5):449-56. doi: 10.1038/nm.3850. Epub 2015 Apr 20.
9
Long-term follow-up after endoscopic resection of gastric superficial neoplastic lesions in Portugal.
Endoscopy. 2014 Nov;46(11):933-40. doi: 10.1055/s-0034-1377348. Epub 2014 Jul 14.
10
Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a single-center retrospective study.
Dig Endosc. 2014 Mar;26(2):183-91. doi: 10.1111/den.12099. Epub 2013 Apr 7.
Zotero 插件