Rheumatology and Clinical Immunology, Spedali Civili Hospital, Brescia, Italy.
Neurology Unit, Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
J Neuroimmunol. 2018 Dec 15;325:61-63. doi: 10.1016/j.jneuroim.2018.10.006. Epub 2018 Oct 19.
Recent studies suggest a role of the autoimmune system dysregulation in Frontotemporal dementia (FTD). In the present study, we performed a broad immunological screening in a large sample of sporadic FTD patients. We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. 13%, p < .001). In FTD, ANA-positive and ANA-negative patients did not differ for any clinical feature. These data extend and further confirm autoimmune dysregulation in FTD. However, it still remains to be clarified whether these antibodies have a potential pathogenic role or represent simply an epiphenomenon.
最近的研究表明，自身免疫系统失调在额颞叶痴呆（FTD）中起作用。在本研究中，我们对大量散发性 FTD 患者进行了广泛的免疫学筛查。与 100 名健康对照组（HC）相比，我们报告了 100 名 FTD 患者的抗核自身抗体（ANA）阳性率显著增加（60% vs. 13%，p <.001）。在 FTD 中，ANA 阳性和 ANA 阴性患者在任何临床特征方面均无差异。这些数据扩展并进一步证实了 FTD 中的自身免疫失调。然而，这些抗体是否具有潜在的致病作用，或者仅仅是一种伴随现象，仍有待阐明。
