额颞叶痴呆中的抗核抗体：自身免疫冰山的一角？
Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?
机构信息
Rheumatology and Clinical Immunology, Spedali Civili Hospital, Brescia, Italy.
Neurology Unit, Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
出版信息
J Neuroimmunol. 2018 Dec 15;325:61-63. doi: 10.1016/j.jneuroim.2018.10.006. Epub 2018 Oct 19.
Recent studies suggest a role of the autoimmune system dysregulation in Frontotemporal dementia (FTD). In the present study, we performed a broad immunological screening in a large sample of sporadic FTD patients. We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. 13%, p < .001). In FTD, ANA-positive and ANA-negative patients did not differ for any clinical feature. These data extend and further confirm autoimmune dysregulation in FTD. However, it still remains to be clarified whether these antibodies have a potential pathogenic role or represent simply an epiphenomenon.
最近的研究表明，自身免疫系统失调在额颞叶痴呆（FTD）中起作用。在本研究中，我们对大量散发性 FTD 患者进行了广泛的免疫学筛查。与 100 名健康对照组（HC）相比，我们报告了 100 名 FTD 患者的抗核自身抗体（ANA）阳性率显著增加（60% vs. 13%，p <.001）。在 FTD 中，ANA 阳性和 ANA 阴性患者在任何临床特征方面均无差异。这些数据扩展并进一步证实了 FTD 中的自身免疫失调。然而，这些抗体是否具有潜在的致病作用，或者仅仅是一种伴随现象，仍有待阐明。
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