Spivak B, Radwan M, Bartur P, Mester R, Weizman A
Research Unit, Ness Ziona Government Psychiatric Hospital, Israel.
Acta Psychiatr Scand. 1995 Oct;92(4):266-9. doi: 10.1111/j.1600-0447.1995.tb09581.x.
We determined the presence of antinuclear autoantibodies (ANA), antinative DNA and histone-reactive ANA in 3 groups of chronic schizophrenic patients (n=85): haloperidol-treated patients (for at least 3 months) (n=35), drug-free for at least 3 months (n=35) and neuroleptic-naive patients (n=15). The autoantibody titers were compared with those of healthy controls (n=37). A significantly higher frequency of positive ANA was found among chronic schizophrenic patients (approximately 20%) as compared with the controls (approximately 5%), irrespective of drug treatment, sex and age. No antinative ANA autoantibodies or histone reactive ANA were detected in either schizophrenic patients or controls. Further studies are needed to isolate and characterize in ANA-positive schizophrenic patients a putative specific ANA profile.
我们测定了3组慢性精神分裂症患者（n = 85）中抗核自身抗体（ANA）、抗天然DNA和组蛋白反应性ANA的存在情况：接受氟哌啶醇治疗至少3个月的患者（n = 35）、至少3个月未用药的患者（n = 35）和未使用过抗精神病药物的患者（n = 15）。将自身抗体滴度与健康对照者（n = 37）的滴度进行比较。与对照组（约5%）相比，慢性精神分裂症患者中ANA阳性的频率显著更高（约20%），与药物治疗、性别和年龄无关。在精神分裂症患者和对照组中均未检测到抗天然ANA自身抗体或组蛋白反应性ANA。需要进一步研究以分离并鉴定ANA阳性精神分裂症患者中假定的特异性ANA谱。
