Katisko Kasper, Cajanus Antti, Korhonen Titta, Remes Anne M, Haapasalo Annakaisa, Solje Eino
Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Neuro Center, Neurology, Kuopio University Hospital, Kuopio, Finland.
Front Neurosci. 2019 Jun 21;13:658. doi: 10.3389/fnins.2019.00658. eCollection 2019.
Despite the current diagnostic criteria, early diagnostics of behavioral variant of frontotemporal dementia (bvFTD) has remained challenging. Patients with bvFTD often present with misleading psychiatric phenotype, and, on the other hand, impairment in memory functions have increasingly been reported. However, impaired episodic memory is currently considered as an exclusion criterion for bvFTD. Single biofluid-based or imaging biomarkers do not currently provide sufficient sensitivity or specificity for early bvFTD diagnosis at single-subject level, although studies have suggested improved accuracy with different biomarker combinations. In this mini review, we evaluate the core clinical features of early bvFTD and summarize the most potential imaging and fluid biomarkers for bvFTD diagnostics.
尽管有当前的诊断标准，但额颞叶痴呆行为变异型（bvFTD）的早期诊断仍然具有挑战性。bvFTD患者常常表现出具有误导性的精神症状，另一方面，越来越多的报告称其存在记忆功能损害。然而，目前发作性记忆受损被视为bvFTD的排除标准。尽管研究表明不同生物标志物组合可提高准确性，但目前单一的基于生物流体或成像的生物标志物在单受试者水平上对bvFTD早期诊断的敏感性或特异性不足。在本综述中，我们评估了早期bvFTD的核心临床特征，并总结了用于bvFTD诊断的最具潜力的成像和流体生物标志物。
