Department of Prosthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China.
National Clinical Research Center for Oral Diseases, Shanghai, China.
Inflammation. 2019 Apr;42(2):548-558. doi: 10.1007/s10753-018-0912-6.
It has been shown that cyclic stretch could induce inflammatory response such as pyroptosis and the release of IL-1β in human periodontal ligament cells, through activating inflammasome and related caspases. Though gasdermin-d (GSDMD) has been reported to be present in some inflammatory diseases and function as a crucial executioner of pyroptosis, the role of GSDMD in the stretch-induced inflammatory response in human periodontal ligament cells (HPDLCs) has not been well clarified. In this study, it was found that GSDMD was activated by cyclic stretch, and its activation affected the pyroptotic rate in HPDLCs, leading to the maturation and secretion of IL-1β and IL-18 ultimately. In addition, GSDMD was found to be regulated by caspase-1 directly. Nevertheless, the exact relationship between inflammasomes and GSDMD in the stretch-induced inflammatory response still needs to be further elucidated.
已有研究表明，周期性牵张可通过激活炎性小体和相关半胱天冬酶，诱导人牙周膜细胞发生炎症反应，如细胞焦亡和白细胞介素-1β（IL-1β）的释放。Gasdermin-D（GSDMD）已被报道存在于一些炎症性疾病中，并作为细胞焦亡的关键执行者发挥作用，但 GSDMD 在周期性牵张诱导的人牙周膜细胞（HPDLC）炎症反应中的作用尚未得到充分阐明。在本研究中发现，周期性牵张可激活 GSDMD，其激活影响 HPDLC 中的细胞焦亡率，最终导致 IL-1β和 IL-18 的成熟和分泌。此外，发现 GSDMD 可被半胱天冬酶-1 直接调控。然而，炎性小体与 GSDMD 在牵张诱导的炎症反应中的具体关系仍需要进一步阐明。
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