Wang Leilei, Wang Chuan, He Hong
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Department of Periodontology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Int J Mol Sci. 2024 Dec 19;25(24):13617. doi: 10.3390/ijms252413617.
People, in increasing numbers, are seeking orthodontic treatment to correct malocclusion, while some of them are suffering from orthodontically induced inflammatory root resorption (OIIRR). Recent evidence suggests that the immune-inflammatory response occurring during bone remodeling may be responsible for OIIRR. Ferroptosis, a new type of programmed cell death (PCD), has been found to have a close interrelation with inflammation during disease progression. While ferroptosis has been extensively studied in bone-related diseases, its role in OIIRR is poorly understood. Considering that the tooth root shares a lot of similar characteristics with bone, it is reasonable to hypothesize that ferroptosis contributes to the development of OIIRR. Nevertheless, direct evidence supporting this theory is currently lacking. In this review, we introduced ferroptosis and elucidated the mechanisms underlying orthodontic tooth movement (OTM) and OIIRR, with a special focus on the pivotal role inflammation plays in these processes. Additionally, we covered recent research exploring the connections between inflammation and ferroptosis. Lastly, we emphasized the important regulatory function of ferroptosis in bone homeostasis. Further investigations are required to clarify the modulation mechanisms of ferroptosis in OIIRR and to develop novel and potential therapeutic strategies for the management of OIIRR.
越来越多的人正在寻求正畸治疗来矫正错牙合畸形，而其中一些人正遭受正畸诱导的炎性牙根吸收（OIIRR）。最近的证据表明，骨重塑过程中发生的免疫炎症反应可能是OIIRR的原因。铁死亡是一种新型的程序性细胞死亡（PCD），已发现在疾病进展过程中与炎症密切相关。虽然铁死亡在骨相关疾病中已得到广泛研究，但其在OIIRR中的作用却知之甚少。考虑到牙根与骨有许多相似的特征，推测铁死亡促成OIIRR的发生是合理的。然而，目前缺乏支持这一理论的直接证据。在这篇综述中，我们介绍了铁死亡，并阐明了正畸牙移动（OTM）和OIIRR的潜在机制，特别关注炎症在这些过程中所起的关键作用。此外，我们涵盖了最近探索炎症与铁死亡之间联系的研究。最后，我们强调了铁死亡在骨稳态中的重要调节功能。需要进一步研究以阐明铁死亡在OIIRR中的调节机制，并开发用于治疗OIIRR的新的潜在治疗策略。
