College of Stomatology, Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.
Front Cell Infect Microbiol. 2022 Aug 16;12:953277. doi: 10.3389/fcimb.2022.953277. eCollection 2022.
Periodontitis is highly prevalent worldwide. It is characterized by periodontal attachment and alveolar bone destruction, which not only leads to tooth loss but also results in the exacerbation of systematic diseases. As such, periodontitis has a significant negative impact on the daily lives of patients. Detailed exploration of the molecular mechanisms underlying the physiopathology of periodontitis may contribute to the development of new therapeutic strategies for periodontitis and the associated systematic diseases. Pyroptosis, as one of the inflammatory programmed cell death pathways, is implicated in the pathogenesis of periodontitis. Progress in the field of pyroptosis has greatly enhanced our understanding of its role in inflammatory diseases. This review first summarizes the mechanisms underlying the activation of pyroptosis in periodontitis and the pathological role of pyroptosis in the progression of periodontitis. Then, the crosstalk between pyroptosis with apoptosis, necroptosis, and NETosis in periodontitis is discussed. Moreover, pyroptosis, as a novel link that connects periodontitis with systemic disease, is also reviewed. Finally, the current challenges associated with pyroptosis as a potential therapeutic target for periodontitis are highlighted.
牙周炎在全球范围内高发。其特征为牙周附着丧失和牙槽骨破坏，不仅导致牙齿脱落，还会加重系统性疾病的恶化。因此，牙周炎对患者的日常生活有重大负面影响。深入探究牙周炎病理生理学的分子机制可能有助于开发牙周炎和相关系统性疾病的新治疗策略。细胞焦亡作为一种炎症程序性细胞死亡途径，与牙周炎的发病机制有关。细胞焦亡领域的进展极大地增进了我们对其在炎症性疾病中的作用的理解。本综述首先总结了牙周炎中细胞焦亡激活的机制以及细胞焦亡在牙周炎进展中的病理作用。然后，讨论了细胞焦亡与细胞凋亡、坏死性凋亡和 NET osis 在牙周炎中的串扰。此外，还综述了细胞焦亡作为连接牙周炎与系统性疾病的新纽带。最后，强调了细胞焦亡作为牙周炎潜在治疗靶点所面临的挑战。
