Bhambhani Anupam, John Nelson, Mathew Amalu
Department of Cardiology, Whitefield, Bangalore, 560066, India; Vydehi Institute of Medical Sciences and Research Centre, Whitefield, Bangalore, 560066, India.
Department of Community Medicine, Whitefield, Bangalore, 560066, India; Vydehi Institute of Medical Sciences and Research Centre, Whitefield, Bangalore, 560066, India.
Indian Heart J. 2018 Sep-Oct;70(5):642-648. doi: 10.1016/j.ihj.2017.11.018. Epub 2017 Nov 22.
Cardiac chamber dimensions are race and anthropometry dependent. We determined the age and gender specific 3-Dimensional echocardiographic (3DE) reference values for dimensions and function of left ventricle (LV) and left atrium (LA) in normal Indian adults.
This single center prospective study enrolled 133 adult Indians free of heart disease and/or hypertensions, subjecting them to 3DE measurements of left atrial (LA) & left ventricular (LV) volumes, function and left ventricular mass (LVM). The higher limits of normal cut-offs were determined for these parameters and their dependency on age, gender and anthropometry were analyzed.
The body surface area (BSA) corrected higher limit cut-offs were: 59.37ml/m for LV end diastolic volume (59.19ml/m and 59.61ml/m for men and women, respectively; P=NS); 23.48ml/m for LV end systolic volume (23.27ml/m2 and 23.11ml/m for men and women, P=NS). Mean LVEF was 64.79%±7.26 (62.99%±6.51 and 67.05%±7.58 in men and women, P=NS). Men had higher LVM than women (119.79g±23.95 vs. 103.26g±23.76, P<0.001), this difference disappeared after BSA indexing. The higher limit cut-offs for normal LA volumes were 20.49ml for minimum volume (21.18ml and 19.46ml for men and women, P=NS) and 39.76ml for maximum volume (39.60ml and 40.03ml in men and women, P=NS). The parameters were smaller compared to western populations but the differences attenuated after BSA indexing.
The study reports normal 3DE parameters of size and function of left heart chambers in Indians.
心腔大小因种族和人体测量学因素而异。我们确定了正常印度成年人左心室（LV）和左心房（LA）大小及功能的年龄和性别特异性三维超声心动图（3DE）参考值。
这项单中心前瞻性研究纳入了133名无心脏病和/或高血压的成年印度人，对他们进行左心房（LA）和左心室（LV）容积、功能及左心室质量（LVM）的3DE测量。确定这些参数的正常上限，并分析它们与年龄、性别和人体测量学的相关性。
体表面积（BSA）校正后的正常上限为：左心室舒张末期容积59.37ml/m²（男性为59.19ml/m²，女性为59.61ml/m²；P=无显著性差异）；左心室收缩末期容积23.48ml/m²（男性为23.27ml/m²，女性为23.11ml/m²，P=无显著性差异）。平均左心室射血分数（LVEF）为64.79%±7.26（男性为62.99%±6.51，女性为67.05%±7.58，P=无显著性差异）。男性的LVM高于女性（119.79g±23.95 vs. 103.26g±23.76，P<0.001），经BSA指数校正后，这种差异消失。左心房正常容积的上限为：最小容积20.49ml（男性为21.18ml，女性为19.46ml，P=无显著性差异），最大容积39.76ml（男性为39.60ml，女性为40.03ml，P=无显著性差异）。与西方人群相比，这些参数较小，但经BSA指数校正后差异减小。
该研究报告了印度人左心腔大小和功能的正常3DE参数。
