Recent advances in mass spectrometry imaging for multiomics application in neurology.

Mass spectrometry imaging (MSI) has emerged as a powerful tool for multiomics study in neurology. MSI combines the multichannel (m/z) measurement capability of mass spectrometers with a surface sampling process that allows for rapid probing and mapping of the characterized intact proteins, proteolytic digested peptides, released glycans, phospholipids, glycolipids, and small metabolites in brain tissues. The present review is focused on the application of MSI to the study of proteomics, glycomics, peptidomics, metabolomics, and lipidomics in mouse brain tissues.