矢车菊素-3-O-芸香糖苷作为一种新型的α-葡萄糖苷酶抑制剂，可改善餐后高血糖。
Pelargonidin-3-O-rutinoside as a novel α-glucosidase inhibitor for improving postprandial hyperglycemia.
机构信息
Department of Food Science and Nutrition, National Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, Zhejiang University, Hangzhou 310058, China.
出版信息
Chem Commun (Camb). 2018 Dec 18;55(1):39-42. doi: 10.1039/c8cc07985d.
A novel strategy for the isolation of anthocyanins was developed by a combination of high-speed countercurrent chromatography (HSCCC) and HPLC techniques. Using this strategy, a novel α-glucosidase inhibitor (pelargonidin-3-O-rutinoside, a natural anthocyanin) was isolated from strawberries. Structural determinants for inhibition of α-glucosidase by Pg3R and the SAR of natural anthocyanins were revealed in detail by enzymatic kinetics and molecular docking analysis.
采用高速逆流色谱（HSCCC）与高效液相色谱（HPLC）联用的方法开发了一种新型花色苷分离策略。利用该策略，从草莓中分离出一种新型α-葡萄糖苷酶抑制剂（矢车菊素-3-O-芸香糖苷，一种天然花色苷）。通过酶动力学和分子对接分析，详细揭示了Pg3R 抑制α-葡萄糖苷酶的结构决定因素和天然花色苷的构效关系。
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