来自内生真菌7951的细胞毒性代谢产物。
Cytotoxic metabolites from the endophytic fungus 7951.
作者信息
Wang Fang, Zhao Wuli, Zhang Conghui, Chang Shanshan, Shao Rongguang, Xing Jianguo, Chen Minghua, Zhang Yixuan, Si Shuyi
机构信息
School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University Shenyang 110016 China
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing 100050 China
出版信息
RSC Adv. 2019 May 21;9(28):16035-16039. doi: 10.1039/c9ra02647a. eCollection 2019 May 20.
The following compounds were isolated from acetate extracts of 7951 solid cultures: demethylchaetocochin C (1) and chaetoperazine A (3), two new epipolythiodioxopiperazine (ETP) alkaloids, a novel pyridine benzamide, 4-formyl--(3'-hydroxypyridin-2'-yl) benzamide (6), and three known ETP derivatives (2, 4, and 5). The structures of these compounds were determined using extensive spectroscopic data analysis. Compounds 1-3, and 6, inhibited the growth of MCF-7, MDA-MB-231, H460 and HCT-8 cells with an IC of 4.5 to 65.0 μM.
从7951固体培养物的乙酸乙酯提取物中分离出以下化合物：去甲基毛壳素C（1）和毛壳哌嗪A（3），两种新的表聚硫代二氧哌嗪（ETP）生物碱，一种新型吡啶苯甲酰胺，4-甲酰基-（3'-羟基吡啶-2'-基）苯甲酰胺（6），以及三种已知的ETP衍生物（2、4和5）。通过广泛的光谱数据分析确定了这些化合物的结构。化合物1-3和6对MCF-7、MDA-MB-231、H460和HCT-8细胞的生长具有抑制作用，半数抑制浓度（IC）为4.5至65.0μM。
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