补救合成及其与核酸代谢的关系。
Salvage syntheses and their relationship to nucleic acid metabolism.
作者信息
Königk E
出版信息
Bull World Health Organ. 1977;55(2-3):249-52.
Abstract
The intraerythrocytic stages of plasmodia are capable of synthesizing purine nucleotides and apparently deoxycytidylate by salvage syntheses. Data obtained by studying the incorporation of radioactive precursor molecules into intact cells and kinetic experiments on purified enzyme preparations suggest biosynthetic routes which, generally, are similar to those of the host's cell metabolism. However, details on the regulation of both the uptake of nucleosides and bases into the intraerythrocytic stages of plasmodia and of the metabolic routes involved in this incorporation are still lacking.
摘要
疟原虫的红细胞内期能够通过补救合成途径合成嘌呤核苷酸，显然也能合成脱氧胞苷酸。通过研究放射性前体分子掺入完整细胞的情况以及对纯化酶制剂进行动力学实验所获得的数据表明，其生物合成途径总体上与宿主细胞代谢的途径相似。然而，关于疟原虫红细胞内期对核苷和碱基的摄取调控以及参与这种掺入的代谢途径的细节仍不清楚。
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