Y.S. is a Visiting Senior Research Fellow, UT Southwestern Medical Center, Dallas, TX.
K.Z. is an Associate Professor of Radiology, McMaster University, Hamilton, Ontario, Canada.
Clin Nucl Med. 2018 Dec;43(12):e439-e452. doi: 10.1097/RLU.0000000000002247.
There are recent advances, namely, a standardized method for reporting therapy response (Hopkins criteria), a multicenter prospective cohort study with excellent negative predictive value of F-FDG PET/CT for N0 clinical neck, a phase III multicenter randomized controlled study establishing the value of a negative posttherapy F-FDG PET/CT for patient management, a phase II randomized controlled study demonstrating radiation dose reduction strategies for human papilloma virus-related disease, and Food and Drug Administration approval of nivolumab for treatment of recurrent head and neck squamous cell carcinoma.
目前已有一些新进展,包括:一种用于报告治疗效果的标准化方法(霍普金斯标准)、一项多中心前瞻性队列研究,该研究显示 F-FDG PET/CT 对 N0 期临床颈部的阴性预测值非常高、一项 III 期多中心随机对照研究证实了治疗后 F-FDG PET/CT 阴性对患者管理的价值、一项 II 期随机对照研究证实了针对人乳头瘤病毒相关性疾病的放射剂量降低策略,以及美国食品和药物管理局批准纳武单抗用于治疗复发性头颈部鳞状细胞癌。
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