Carter R, Walliker D
Bull World Health Organ. 1977;55(2-3):339-45.
Genetic differences between micro-organisms can be identified by studying variations in enzyme forms and DNA characteristics. Enzyme electrophoresis has revealed considerable genetic diversity in populations of malarial parasites and has enabled populations reproductively isolated from one another to be identified. Studies on rodent malarial parasites from four regions of Africa have shown that each species and subspecies can be distinguished by its pattern of enzyme forms. In subspecies in which enzyme polymorphism occurs, the frequencies of each combination of enzyme forms suggest an extensive degree of random mating in the population. Populations of Plasmodium falciparum are also enzymically polymorphic, similar enzyme variants being found in isolates from several parts of the world.
通过研究酶形式和DNA特征的变异，可以识别微生物之间的遗传差异。酶电泳揭示了疟原虫种群中存在相当大的遗传多样性，并能够识别出彼此生殖隔离的种群。对来自非洲四个地区的啮齿动物疟原虫的研究表明，每个物种和亚种都可以通过其酶形式模式来区分。在出现酶多态性的亚种中，每种酶形式组合的频率表明该种群中存在广泛程度的随机交配。恶性疟原虫种群也存在酶多态性，在来自世界几个地区的分离株中发现了相似的酶变体。
