The genetic basis of diversity in malaria parasites.

The principal findings of the P. falciparum surveys are given below. Considerable diversity of enzymes, antigens, drug sensitivity and other characters is seen among P. falciparum isolates. Cloning studies show that certain isolates contain mixtures of parasites which may be diverse in one or more of these characters. No obvious regional distribution is seen in the enzymic and antigenic characters examined, although differences in the frequencies of certain enzymes appear to exist. Variations in drug sensitivity are seen among parasites from different regions, the occurrence of resistant forms usually being correlated with the extent of use of the drug concerned.