Walliker D
Adv Parasitol. 1983;22:217-59. doi: 10.1016/s0065-308x(08)60463-7.
The principal findings of the P. falciparum surveys are given below. Considerable diversity of enzymes, antigens, drug sensitivity and other characters is seen among P. falciparum isolates. Cloning studies show that certain isolates contain mixtures of parasites which may be diverse in one or more of these characters. No obvious regional distribution is seen in the enzymic and antigenic characters examined, although differences in the frequencies of certain enzymes appear to exist. Variations in drug sensitivity are seen among parasites from different regions, the occurrence of resistant forms usually being correlated with the extent of use of the drug concerned.
恶性疟原虫调查的主要结果如下。在恶性疟原虫分离株中可观察到酶、抗原、药物敏感性及其他特征存在相当大的多样性。克隆研究表明，某些分离株含有寄生虫混合物，这些寄生虫在这些特征中的一个或多个方面可能存在差异。在所检测的酶和抗原特征方面未观察到明显的区域分布，尽管某些酶的频率似乎存在差异。不同地区的寄生虫之间存在药物敏感性差异，耐药形式的出现通常与相关药物的使用程度相关。
