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累及眼附属器的T细胞淋巴母细胞淋巴瘤:2例报告并复习当前文献

T-cell lymphoblastic lymphoma involving the ocular adnexa: report of two cases and review of the current literature.

作者信息

Sun Lucy, Friedman Alan H, Rodgers Rand, Schear Matthew, Greaves Giovanni, Freidl Kathryn B

机构信息

Department of Ophthalmology, Northwell Health , Great Neck , NY , USA.

Department of Ophthalmology, Mount Sinai Hospital , New York , NY , USA.

出版信息

Orbit. 2019 Oct;38(5):412-418. doi: 10.1080/01676830.2018.1540013. Epub 2018 Nov 6.

Abstract

The majority of ocular adnexal lymphomas are B-cell in origin. We report two cases of T-cell lymphoblastic lymphoma (T-LBL) involving the ocular adnexa. One patient presented with a painless pink conjunctival lesion and inferior orbital fullness. The second patient presented with a painless orbital mass. The diagnoses were confirmed by histopathology and immunohistochemistry. Both patients had extensive multifocal lesions during staging. Prompt intensified chemotherapy regimens were initiated. T-LBL is an aggressive disease with poor prognosis. This report emphasizes the importance of timely diagnosis by the ophthalmologist with co-management and treatment with an oncologist.

摘要

大多数眼附属器淋巴瘤起源于B细胞。我们报告2例累及眼附属器的T细胞淋巴母细胞淋巴瘤(T-LBL)。1例患者表现为无痛性粉红色结膜病变和眶下饱满。第2例患者表现为无痛性眼眶肿物。诊断经组织病理学和免疫组化证实。2例患者分期时均有广泛的多灶性病变。启动了迅速强化的化疗方案。T-LBL是一种侵袭性疾病,预后较差。本报告强调眼科医生及时诊断并与肿瘤学家共同管理和治疗的重要性。

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