Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, Japan.
Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, Japan
J Cell Sci. 2018 Nov 5;131(21):jcs222836. doi: 10.1242/jcs.222836.
SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold protein involved in diverse cellular processes. Its functions are tightly regulated through an extensive pattern of post-translational modifications, and include the isolation of cargos degraded by autophagy, induction of the antioxidant response by the Keap1-Nrf2 system, as well as the regulation of endosomal trafficking, apoptosis and inflammation. Accordingly, malfunction of SQSTM1 is associated with a wide range of diseases, including bone and muscle disorders, neurodegenerative and metabolic diseases, and multiple forms of cancer. In this Review, we summarize current knowledge regarding regulation, post-translational modifications and functions of SQSTM1, as well as how they are dysregulated in various pathogenic contexts.
SQSTM1（也称为 p62）是一种多功能应激诱导支架蛋白，参与多种细胞过程。其功能通过广泛的翻译后修饰模式进行严格调节，包括自噬降解货物的隔离、Keap1-Nrf2 系统诱导抗氧化反应，以及调节内体运输、细胞凋亡和炎症。因此，SQSTM1 的功能障碍与多种疾病有关，包括骨骼和肌肉疾病、神经退行性和代谢疾病以及多种形式的癌症。在这篇综述中，我们总结了目前关于 SQSTM1 的调节、翻译后修饰和功能的知识，以及它们在各种致病环境中失调的情况。
