Department of Veterans Affairs Medical Center, White River Junction, VT, USA. The Geisel School of Medicine at Dartmouth & The Dartmouth Institute, Hanover, NH, USA.
Am J Gastroenterol. 2018 Dec;113(12):1757-1759. doi: 10.1038/s41395-018-0400-5. Epub 2018 Nov 5.
Systematic application of the fecal immunochemical test (FIT) as a screen for colorectal cancer has been shown to meaningfully impact colorectal cancer incidence and mortality. However, there is room for improvement. FIT performance is impacted by a host of patient level factors such as sex and medication use. Meta-analysis has defined those factors most likely to result in a false positive or false negative test. Further work determining how best to gather information on important factors and incorporate them into the FIT result will further enhance the accuracy and outcomes accomplished with this valuable screening test.
系统应用粪便免疫化学试验（FIT）筛查结直肠癌已被证明可显著影响结直肠癌的发病率和死亡率。然而，仍有改进的空间。FIT 的性能受多种患者因素的影响，如性别和药物使用。荟萃分析已经确定了那些最有可能导致假阳性或假阴性检测的因素。进一步的工作确定如何最好地收集重要因素的信息并将其纳入 FIT 结果，将进一步提高这种有价值的筛查试验的准确性和结果。
