Grinevich Iu A, Iugrinova L G, El'chits T V
Vopr Onkol. 1987;33(7):47-50.
Hyperproduction of chorionic gonadotropin was shown to be the first link in the chain of hormonal disturbances involved in trophoblastic disease, which induced changes of pituitary gonadotropic function. Ovarian function is affected by disturbances in trophoblastic and pituitary gonadotropic functions and depends on the extension and severity of the disease. This makes a case for corrective hormonal therapy in chorionepithelioma patients resistant to cytostatic or substitution therapy with sex hormones and in whom ovaries have been removed during combined treatment.
绒毛膜促性腺激素的过度产生被证明是滋养层疾病所涉及的激素紊乱链中的第一个环节，它会引起垂体促性腺功能的变化。卵巢功能受滋养层和垂体促性腺功能紊乱的影响，并取决于疾病的范围和严重程度。这为对细胞抑制或性激素替代疗法耐药且在联合治疗期间已切除卵巢的绒毛膜上皮癌患者进行纠正性激素治疗提供了依据。
