Douaiher Jeffrey, Langenfeld Sean J
Kaiser Permanente Medical Center, Walnut Creek, CA; Division of General Surgery, Kaiser Permanente Northern California, Oakland, CA.
Clin Colon Rectal Surg. 2018 Nov;31(6):361-367. doi: 10.1055/s-0038-1668106. Epub 2018 Nov 2.
The incidence of anal intraepithelial neoplasia (AIN) has been increasing over the years. AIN acts as a precursor lesion for anal squamous cell cancer. Factors leading to progression of AIN into malignancy are complex and involve grade of the lesion, human papillomavirus and HIV coinfection, as well as patient-related risk factors such as immunocompromised state and men who have sex with men. The multifaced aspects of this disease make its management challenging, as it involves several disciplines including pathology, primary care, infectious disease, and colorectal specialties. Each of these fields brings its own expertize to the management of AIN, and their collaborative, coordinated work culminates into best practice and optimized outcomes in the care of the AIN patient.
近年来，肛管上皮内瘤变（AIN）的发病率一直在上升。AIN是肛门鳞状细胞癌的前驱病变。导致AIN进展为恶性肿瘤的因素很复杂，包括病变分级、人乳头瘤病毒和HIV合并感染，以及患者相关的风险因素，如免疫功能低下状态和男男性行为者。这种疾病的多方面特性使其管理具有挑战性，因为它涉及多个学科，包括病理学、初级保健、传染病和结直肠专科。这些领域中的每一个都为AIN的管理带来了自己的专业知识，它们的协作、协调工作最终形成了最佳实践，并在AIN患者的护理中实现了优化的结果。
