Richter P, Buchholz K, Lotze W
Zentralbl Gynakol. 1987;109(9):586-9.
In our department 24 patients underwent treatment of invasive trophoblastic tumours from 1975 to 1984. In 13 cases we were dealing with invasive bladder moles and in 11 cases with chorionic carcinoma. Nine women became pregnant, among them one case of chorionic carcinoma. Eight women were delivered of a viable child on average 30 months after the end of the treatment, whereas one patient wanted termination of pregnancy. Six women had undergone a methotrexate monotherapy before, two women a sequential treatment with methotrexate + actinomycine D. The undisturbed pregnancies and births of eight healthy babies point to an unimpaired fertility after chemotherapy of trophoblastic tumours.
1975年至1984年期间,我科对24例侵袭性滋养细胞肿瘤患者进行了治疗。其中13例为侵袭性膀胱葡萄胎,11例为绒毛膜癌。9名女性怀孕,其中1例为绒毛膜癌。8名女性在治疗结束后平均30个月分娩出活婴,而1名患者要求终止妊娠。6名女性此前接受过甲氨蝶呤单药治疗,2名女性接受过甲氨蝶呤 + 放线菌素D序贯治疗。8名健康婴儿顺利妊娠和出生,表明滋养细胞肿瘤化疗后生育能力未受损害。