Amr M F
Department of Obstetrics and Gynecology, Jordan University Hospital, Amman.
Int J Fertil Womens Med. 1999 May-Jun;44(3):146-9.
To determine the effect of chemotherapy on patients who wished to conceive after successful treatment of gestational trophoblastic disease. Patients-During a 12-year period (1984-1995), 90 patients with gestational trophoblastic tumor at Jordan University Hospital received repeated courses of chemotherapy; 85 patients are in continued remission (42 invasive mole and 43 choriocarcinoma). Fifty-five patients wished to conceive. Main outcome measures-Pregnancy, live births.
Forty-two patients (76%) achieved pregnancy, resulting in 20 pregnancies and 94 viable babies.
Chemotherapy is very effective in the cure of gestational trophoblastic tumors. Return of fertility compares favorably with the general population of the same reproductive age. There appears to be no increase in fetal congenital malformations.
确定化疗对成功治疗妊娠滋养细胞疾病后希望怀孕的患者的影响。患者——在12年期间（1984 - 1995年），约旦大学医院90例妊娠滋养细胞肿瘤患者接受了多疗程化疗；85例患者持续缓解（42例侵蚀性葡萄胎和43例绒毛膜癌）。55例患者希望怀孕。主要观察指标——妊娠、活产。
42例患者（76%）成功妊娠，共有20次妊娠和94个活产婴儿。
化疗对治愈妊娠滋养细胞肿瘤非常有效。生育能力的恢复与同一年龄段的普通人群相比良好。胎儿先天性畸形似乎没有增加。
