外泌体在肝细胞癌中新兴作用的研究进展。

Department of Medical Oncology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China.

Department of Medical Oncology, Jinling Hospital, Nanjing Medical University, Nanjing, China.

Cell Prolif. 2019 Mar;52(2):e12541. doi: 10.1111/cpr.12541. Epub 2018 Nov 5.

Exosomes are small membrane vesicles 50-150 nm in diameter released by a variety of cells, which contain miRNAs, mRNAs and proteins with the potential to regulate signalling pathways in recipient cells. Exosomes deliver nucleic acids and proteins to participate in orchestrating cell-cell communication and microenvironment modulation. In this review, we summarize recent progress in our understanding of the role of exosomes in hepatocellular carcinoma (HCC). This review focuses on recent studies on HCC exosomes, considering biogenesis, cargo and their effects on the development and progression of HCC, including chemoresistance, epithelial-mesenchymal transition, angiogenesis, metastasis and immune response. Finally, we discuss the clinical application of exosomes as a therapeutic agent for HCC.

外泌体是直径为 50-150nm 的小膜囊泡，由多种细胞释放，其中包含具有调节受体细胞信号通路潜力的 miRNA、mRNA 和蛋白质。外泌体通过传递核酸和蛋白质来参与协调细胞间通讯和微环境调节。在这篇综述中，我们总结了近年来对外泌体在肝细胞癌（HCC）中的作用的理解进展。本综述重点关注 HCC 外泌体的最新研究，考虑了其生物发生、货物及其对 HCC 发展和进展的影响，包括化疗耐药性、上皮-间充质转化、血管生成、转移和免疫反应。最后，我们讨论了外泌体作为 HCC 治疗剂的临床应用。