Liu Yong-Qiang, Chen Feng, Zhang Fa, Ye Yuan-Mei, Su Yu-Jie, Liu Ya-Tao, Leng Yu-Fang
The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, GanSu Province, China.
Department of Anesthesiology, First Hospital of Lanzhou University, Lanzhou, 730000, GanSu Province, China.
Mol Biol Rep. 2025 Mar 10;52(1):295. doi: 10.1007/s11033-025-10393-7.
tRNA-derived small RNAs (tsRNAs) is a type of non-coding RNA that is present in large quantities in humans and exhibits high stability. It plays a crucial role in various physiological processes and diseases. In recent years, research on tsRNAs in tumors has expanded significantly, revealing its regulatory effects in non-neoplastic diseases as well. Additionally, tsRNAs has been extensively studied in the context of digestive system diseases, encompassing both digestive system tumors and non-tumor conditions. It is believed to influence the biological characteristics of diseases as well as clinical pathological features. Given its potential, tsRNAs is anticipated to have broad applications in disease diagnosis and prognosis prediction, and it is expected to emerge as a new class of biomarkers. Nevertheless, numerous issues remain that require in-depth discussion. This article presents an overview of the characteristics and roles of tsRNAs in digestive system diseases, aiming to provide a comprehensive perspective and to inspire new ideas for the diagnosis and treatment of these conditions.
转运RNA衍生的小RNA（tsRNAs）是一类非编码RNA，在人体内大量存在且具有高度稳定性。它在各种生理过程和疾病中发挥着关键作用。近年来，关于肿瘤中tsRNAs的研究显著扩展，同时也揭示了其在非肿瘤性疾病中的调节作用。此外，tsRNAs在消化系统疾病领域，包括消化系统肿瘤和非肿瘤疾病方面都得到了广泛研究。据信它会影响疾病的生物学特性以及临床病理特征。鉴于其潜力，tsRNAs有望在疾病诊断和预后预测中得到广泛应用，并有望成为一类新型生物标志物。然而，仍有许多问题需要深入探讨。本文概述了tsRNAs在消化系统疾病中的特征和作用，旨在提供全面的视角，并为这些疾病的诊断和治疗激发新的思路。
