Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore, Pakistan.
Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL, USA.
Biotechnol Adv. 2018 Jan-Feb;36(1):328-334. doi: 10.1016/j.biotechadv.2017.12.010. Epub 2017 Dec 14.
A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles, known as exosomes, which regulate the cellular behavior of recipient cells following uptake. Based on the impressive capacity of exosomes in delivering their "payload", different therapeutic agents, are currently being tested using this delivery method for more effective therapy. This review summarizes the most recent developments in exosome bioactivities and discusses the biochemical nature of exosomes and their biogenesis. It also summarizes the use of exosomes as delivery vehicles for drugs and natural compounds to the targeted site.
越来越多的实验证据开始揭示调节细胞内和细胞间通讯的广泛分子机制。近年来，人们才发现了大量的相关知识，我们逐渐了解到供体细胞会释放纳米囊泡，即外泌体，这些囊泡在被受体细胞摄取后会调节受体细胞的行为。基于外泌体在传递“有效载荷”方面的惊人能力，目前正在使用这种传递方法来测试不同的治疗药物，以实现更有效的治疗。本文综述了外泌体生物活性的最新研究进展，讨论了外泌体的生化特性及其发生过程。还总结了外泌体作为药物和天然化合物递送至靶向部位的载体的应用。
