College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for, Chemical Imaging in Universities of Shandong, Institute of, Molecular and Nano Science, Shandong Normal University, Jinan, 250014, P. R. China.
Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1057-1061. doi: 10.1002/anie.201811273. Epub 2018 Dec 20.
The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual-targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual-targeted photothermal agent.
开发高效的抗癌药物，使其对周围正常组织的损伤最小化，是癌症治疗中的一个挑战性课题。在此，我们展示了一种双重靶向的有机分子，它通过主动靶向肿瘤组织和线粒体来选择性地杀死癌细胞，从而发挥光热剂的作用。合成的光热剂表现出较高的光热转换效率、低细胞毒性和良好的生物相容性。体内实验表明，双重靶向光热剂具有优异的肿瘤抑制作用。
