Wang Qihui, Wang Guoliang, Li Xinru, Li Di, Zhang Congxiao, Ding Jianxun
Department of Stomatology, The First Hospital of Jilin University, 1 Xinmin Street, Changchun, 130061, P. R. China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, P. R. China.
Adv Sci (Weinh). 2025 Mar;12(9):e2412561. doi: 10.1002/advs.202412561. Epub 2025 Jan 3.
Dentin hypersensitivity (DH), marked by exposed dentinal tubules, presents as a sharp toothache triggered by stimuli and subsides when the stimuli are removed. To address the limitations of current commercial desensitizers in terms of acid resistance, friction resistance, and stability, a black phosphorus nanosheet-composited methacrylate gelatin hydrogel (GelMA/BP) is developed for DH treatment, leveraging the synergistic effects of photothermal therapy and biomineralization. Incorporating the BP nanosheet provided GelMA/BP with a stable photothermal response and the continuous release of phosphate anions, which blocked dentinal tubules by converting light energy into heat and initiating biomineralization. In vitro desensitizing therapy showed that the dentinal tubule diameter in the GelMA/BP50 group (0-1.13 µm) is significantly reduced compared to that in the DH-model group (0-3.14 µm). The GelMA/BP50 group achieved an 86% tubule occlusion rate, with acid resistance of 80%, friction resistance of 76%, and long-term stability of 74%. In vivo studies further validated the efficacy of GelMA/BP50, showing a reduction in tubule diameter (0-0.37 µm) and an occlusion rate of 79%, which alleviated toothache and increased intake and weight. These results demonstrate that this desensitizing hydrogel acts as an effective dentinal tubule sealant, offering promising clinical benefits for the topical treatment of DH.
牙本质过敏症（DH）以牙本质小管暴露为特征，表现为受刺激引发的尖锐牙痛，刺激去除后疼痛缓解。为解决当前市售脱敏剂在耐酸性、耐摩擦性和稳定性方面的局限性，开发了一种用于治疗DH的黑磷纳米片复合甲基丙烯酸明胶水凝胶（GelMA/BP），利用光热疗法和生物矿化的协同作用。加入BP纳米片使GelMA/BP具有稳定的光热响应和磷酸根阴离子的持续释放，通过将光能转化为热能并启动生物矿化来封闭牙本质小管。体外脱敏治疗表明，与DH模型组（0 - 3.14 µm）相比，GelMA/BP50组的牙本质小管直径（0 - 1.13 µm）显著减小。GelMA/BP50组的小管封闭率达到86%，耐酸性为80%，耐摩擦性为76%，长期稳定性为74%。体内研究进一步验证了GelMA/BP50的疗效，显示小管直径减小（0 - 0.37 µm），封闭率为79%，缓解了牙痛，增加了摄入量和体重。这些结果表明，这种脱敏水凝胶可作为一种有效的牙本质小管封闭剂，为DH的局部治疗提供了有前景的临床益处。
