Ogilvie Adam T, Brisson Brigitte A, Gow William R, Wainberg Shannon, Singh Ameet, Weese J Scott
J Am Vet Med Assoc. 2018 Nov 15;253(10):1289-1293. doi: 10.2460/javma.253.10.1289.
OBJECTIVE To determine the effects of silver-coated versus standard silicone urinary catheters on the incidence of catheter-associated bacteriuria (CAB) and catheter-associated urinary tract infection (CAUTI) in dogs. DESIGN Randomized controlled clinical trial. ANIMALS 36 dogs requiring urinary bladder catheterization for ≥ 24 hours. PROCEDURES Dogs were randomly assigned to receive a silver-coated or non-silver-coated (control) silicone Foley catheter. Urine samples for cytologic examination and bacterial culture were collected at the time of catheter insertion and daily until catheters were removed (≥ 24 hours to 7 days later). Results were compared between groups. RESULTS No significant differences were identified between catheter groups in the incidence of CAB or CAUTI. Although the median time to development of cytologically detected bacteriuria, culture-detected bacteriuria, and CAUTI did not differ significantly between groups, median time to CAB development (either method) was significantly longer for dogs that received a control catheter rather than a silver-coated catheter. For both types of catheters combined, older age was a significant predictor of culture-detected bacteriuria, and longer duration of catheterization was a significant predictor of culture-detected bacteriuria and overall CAB. CONCLUSIONS AND CLINICAL RELEVANCE Silver-coated urinary catheters provided no clinical benefit over standard urinary catheters for the dogs of this study and were associated with earlier development of CAB but not CAUTI. A larger prospective study is required to definitively determine whether the use of silver-coated urinary catheters should or should not be considered to reduce the risk of CAB or CAUTI in dogs.
目的 确定镀银硅胶导尿管与标准硅胶导尿管对犬导尿管相关菌尿(CAB)和导尿管相关尿路感染(CAUTI)发生率的影响。 设计 随机对照临床试验。 动物 36只需要膀胱插管≥24小时的犬。 方法 将犬随机分配接受镀银或未镀银(对照)硅胶Foley导尿管。在插管时以及每天直至导尿管拔除(≥24小时至7天后)收集尿液样本进行细胞学检查和细菌培养。对组间结果进行比较。 结果 在CAB或CAUTI发生率方面,导尿管组之间未发现显著差异。尽管在细胞学检测到菌尿、培养检测到菌尿和CAUTI发生的中位时间上,组间无显著差异,但接受对照导尿管而非镀银导尿管的犬,CAB发生的中位时间(任何一种方法)显著更长。对于两种类型的导尿管合并来看,年龄较大是培养检测到菌尿的显著预测因素,而较长的插管持续时间是培养检测到菌尿和总体CAB的显著预测因素。 结论及临床意义 对于本研究中的犬,镀银导尿管相较于标准导尿管未提供临床益处,且与CAB更早发生相关,但与CAUTI无关。需要进行更大规模的前瞻性研究来明确确定是否应考虑使用镀银导尿管以降低犬CAB或CAUTI的风险。