Kanti S P Yamini, Csóka Ildikó, Jójárt-Laczkovich Orsolya, Adalbert Lívia
Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Biomedicines. 2022 Oct 14;10(10):2580. doi: 10.3390/biomedicines10102580.
In recent years, we have witnessed prominent improvements in urinary catheter coatings to tackle the commonly occurring catheter-associated urinary tract infection (CAUTI) in catheterized patients. CAUTIs are claimed to be one of the most frequent nosocomial infections that can lead to various complications, from catheter encrustation to severe septicaemia and pyelonephritis. Besides general prevention hygienic strategies, antimicrobial-coated urinary catheters show great potential in the prevention of urinary catheter-associated complications. The aim of this review is to present and evaluate recent updates on the development of antimicrobial urinary catheters in the context of the aetiology of urinary malfunction. Subsequently, we shed some light on future perspectives of utilizing 3D printing and the surrounding regulatory directions.
近年来,我们目睹了导尿管涂层的显著改进,以应对导尿患者中常见的导管相关性尿路感染(CAUTI)。CAUTIs被认为是最常见的医院感染之一,可导致从导管结痂到严重败血症和肾盂肾炎等各种并发症。除了一般的预防卫生策略外,抗菌涂层导尿管在预防导尿管相关并发症方面显示出巨大潜力。本综述的目的是在尿路功能障碍病因学的背景下,介绍和评估抗菌导尿管发展的最新进展。随后,我们阐述了利用3D打印的未来前景以及相关的监管方向。