Heath R B, Malpas J S, Kangro H O, Ward A, McEniery J M, Kingston J E
Arch Dis Child. 1987 Jun;62(6):569-72. doi: 10.1136/adc.62.6.569.
Thirty nine children with malignant disease and without antibodies to varicella zoster virus were immunised with a live Oka strain varicella vaccine. Seroconversion was shown in 24 of those who were vaccinated but five of 18 who responded to the vaccine who were followed up for over six months subsequently lost their antibodies. Of 10 children who were revaccinated, nine responded to the second dose but three lost their antibodies within six months to two years. Four children developed reactions related to the vaccine, one local and three generalised, but all these were transitory and of no clinical concern. Nine of those who were vaccinated, including four who did not respond to the vaccine, have subsequently had close exposure to varicella but none has developed the disease.
39名患有恶性疾病且无水痘带状疱疹病毒抗体的儿童接种了Oka株水痘活疫苗。接种疫苗的儿童中有24人出现了血清转化，但在接种疫苗且随后随访超过6个月的18名有反应的儿童中，有5人后来失去了抗体。在10名再次接种疫苗的儿童中，9人对第二剂有反应，但3人在6个月至2年内失去了抗体。4名儿童出现了与疫苗相关的反应，1例为局部反应，3例为全身反应，但所有这些反应都是暂时的，无临床问题。接种疫苗的儿童中有9人，包括4名对疫苗无反应的儿童，随后密切接触了水痘，但无人发病。
