Heath R B, Malpas J S
Postgrad Med J. 1985;61 Suppl 4(721):107-11.
A comparative evaluation of radioimmunoassay (RIA), indirect immunofluorescence, fluorescent antibody to membrane antigen, competitive inhibition RIA, and complement fixation methods for determining the immune status to varicella-zoster virus (VZV) showed that RIA was the most sensitive test. However, this test is still not regarded as being entirely satisfactory and possible reasons are discussed. To date, 28 children, mainly with solid tumours, have been inoculated with the Oka-strain live varicella vaccine. Two of these vaccinees developed minor reactions, but only 62% developed a RIA-detectable humoral response. Approximately 46% of the responders had lost induced antibody within 12 months of vaccination. None of the 6 vaccinees that have subsequently been in contact with varicella developed any illness suggesting that they had been protected.
对放射免疫测定（RIA）、间接免疫荧光法、膜抗原荧光抗体法、竞争性抑制RIA以及补体结合法用于确定水痘-带状疱疹病毒（VZV）免疫状态的比较评估表明，RIA是最敏感的检测方法。然而，该检测方法仍未被认为完全令人满意，并对可能的原因进行了讨论。迄今为止，28名主要患有实体瘤的儿童接种了Oka株水痘活疫苗。其中两名接种者出现了轻微反应，但只有62%的人产生了RIA可检测到的体液反应。约46%的反应者在接种疫苗后的12个月内抗体消失。随后接触过水痘的6名接种者中，没有一人出现任何疾病，这表明他们受到了保护。
