Cooper M E, Murray R M, Kalnins R, Woodward J, Jerums G
Aust N Z J Med. 1987 Apr;17(2):249-51. doi: 10.1111/j.1445-5994.1987.tb00055.x.
A 60 year old woman originally presented with headache. Investigations revealed a pituitary tumour and endocrine investigations at that time showed normal plasma cortisol levels. Seven years after removal of this tumour, the patient developed the clinical and biochemical features of Cushing's disease. Immunoperoxidase staining of the original tumour was positive for adrenocorticotrophic hormone. This report suggests that immunocytochemistry may have an important role in the routine evaluation of pituitary tumours.
一名60岁女性最初因头痛就诊。检查发现垂体瘤，当时的内分泌检查显示血浆皮质醇水平正常。切除该肿瘤7年后，患者出现了库欣病的临床和生化特征。原肿瘤的免疫过氧化物酶染色显示促肾上腺皮质激素呈阳性。本报告提示免疫细胞化学在垂体瘤的常规评估中可能具有重要作用。
