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[儿童癌症幸存者的长期随访——德国儿科肿瘤与血液学会(GPOH)“长期随访”工作组2018年关于儿科肿瘤患者长期监测、长期随访和迟发效应评估的立场文件]

[Long-Term Follow-Up in Childhood Cancer Survivors - Position paper 2018 of the working group "long-term follow-up" of the Society of Pediatric Oncology and Hematology (GPOH) on long-term surveillance, long-term follow-up and late effect evaluation in pediatric oncology patients].

作者信息

Langer Thorsten, Grabow Desiree, Kaatsch Peter, Creutzig Ursula, Eggert Angelika, Escherich Gabriele, Calaminus Gabriele

机构信息

Pädiatrische Onkologie und Hämatologie, Klinik für Kinder- und Jugendmedizin, Lübeck.

Institut für Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Deutsches Kinderkrebsregister (DKKR), Mainz.

出版信息

Klin Padiatr. 2018 Oct;230(6):291-298. doi: 10.1055/a-0754-2362. Epub 2018 Nov 6.

Abstract

Nowadays, childhood cancer patients survive much more often than they did 40 years ago. Therefore, the cure rates rise over 80%. Approximately 33,000 cured childhood cancer patients are documented by the German Childhood Cancer Registry (GCCR) for long-term follow-up in Germany. But does that mean, they are healthy, too? When compared to the normal population, it can be seen that morbidity and mortality are significantly higher among former childhood cancer patients. In two out of three survivors, the cancer and its treatments can lead to treatment-related late complications 30 years later; in about one-third, these late complications are classified as severe. A structured long-term follow-up is needed to detect and to treat new diseases early. The purpose of this position paper is to update the first position paper from 2007. Current developments are described, how appropriate aftercare structures and aftercare facilities should be planned, taking into account existing structures and increasing needs.

摘要

如今,儿童癌症患者的生存率比40年前高得多。因此,治愈率超过了80%。德国儿童癌症登记处(GCCR)记录了约33000名治愈的儿童癌症患者,以便在德国进行长期随访。但这是否意味着他们也很健康呢?与正常人群相比,可以发现 former childhood cancer patients 的发病率和死亡率明显更高。在三分之二的幸存者中,癌症及其治疗可能会在30年后导致与治疗相关的晚期并发症;在大约三分之一的患者中,这些晚期并发症被归类为严重并发症。需要进行结构化的长期随访,以便早期发现和治疗新疾病。本立场文件的目的是更新2007年的第一份立场文件。描述了当前的发展情况,以及应如何规划适当的后续护理结构和后续护理设施,同时考虑到现有结构和不断增加的需求。 (注:原文中“former childhood cancer patients”直译为“以前的儿童癌症患者”,结合语境这里可能是指“曾经患过儿童癌症的患者”,但按照要求未做修改。)

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