Archer C B, Dalton N, Turner C, Macdonald D M
Br J Dermatol. 1987 Jun;116(6):793-800. doi: 10.1111/j.1365-2133.1987.tb04897.x.
Adrenomedullary function in patients with atopic dermatitis was assessed by measurement of plasma levels of catecholamines (adrenalin and noradrenalin) and cyclic AMP in response to the stimuli of standing after lying supine, and a 5-min infusion of histamine in the standing position (i.e. histamine plus standing). Plasma clearance of adrenalin was examined by measurement of plasma catecholamine and cyclic AMP levels following a 15-min intravenous infusion of adrenalin in the supine position. Resting plasma levels of adrenalin, cyclic AMP and noradrenalin were not statistically different in atopic patients and normal controls. Standing or intravenous infusion of histamine in the standing position caused a rise in plasma catecholamine levels. Plasma adrenalin, cyclic AMP and noradrenalin levels in response to these stimuli and the rate of clearance of exogenous adrenalin from the plasma were not significantly different in patients with atopic dermatitis and in normal subjects.
通过测量血浆中儿茶酚胺（肾上腺素和去甲肾上腺素）水平以及环磷酸腺苷（cAMP）水平，对特应性皮炎患者的肾上腺髓质功能进行评估，这些测量是在患者仰卧位后站立的刺激下以及站立位5分钟输注组胺（即组胺加站立）后进行的。通过在仰卧位静脉输注肾上腺素15分钟后测量血浆儿茶酚胺和环磷酸腺苷水平，来检测肾上腺素的血浆清除率。特应性皮炎患者和正常对照组静息状态下的血浆肾上腺素、环磷酸腺苷和去甲肾上腺素水平在统计学上无差异。站立或站立位静脉输注组胺会导致血浆儿茶酚胺水平升高。在这些刺激下，特应性皮炎患者和正常受试者的血浆肾上腺素、环磷酸腺苷和去甲肾上腺素水平以及外源性肾上腺素从血浆中的清除率无显著差异。
