Crespi H, Armando I, Tumilasci O, Levin G, Massimo J, Barontini M, Perec C
J Invest Dermatol. 1982 Jun;78(6):493-7. doi: 10.1111/1523-1747.ep12510303.
The purpose of this study was to evaluate the in vivo state of both branches of the autonomic nervous system in children with chronic atopic dermatitis. In 15 patients, age 4 to 11, the following parameters were analyzed: (1) basal plasma levels of epinephrine, norepinephrine, and dopamine; (2) poststimulation (standing and i.v. furosemide administration); (3) basal urinary excretion of epinephrine, norepinephrine, and vainillin mandelic acid; (4) 30 min postfurosemide administration; (5) parotid secretory response to intraoral 0.1 m citric acid: flow rate, saliva pH, and concentrations of bicarbonate, chlorides, inorganic phosphates, total protein, and amylase activity. No differences in plasma and urinary basal levels of the catecholamines were observed. In response to standing, plasma norepinephrine from atopic children showed a greater increase than that seen in normal healthy children. From the salivary factors studied, no differences were found in parotid flow-rate, bicarbonates, chlorides, and inorganic phosphates. Protein concentration as well as amylase activity were significantly decreased in children with atopic dermatitis. These findings suggest that in atopic dermatitis, the beta-sympathetic mediated responses are impaired; on the other hand, parasympathetic mediated responses remain preserved.
本研究的目的是评估慢性特应性皮炎患儿自主神经系统两个分支的体内状态。对15名4至11岁的患者进行了以下参数分析：（1）肾上腺素、去甲肾上腺素和多巴胺的基础血浆水平；（2）刺激后（站立及静脉注射速尿）；（3）肾上腺素、去甲肾上腺素和香草扁桃酸的基础尿排泄量；（4）速尿注射后30分钟；（5）腮腺对口腔内0.1m柠檬酸的分泌反应：流速、唾液pH值以及碳酸氢盐、氯化物、无机磷酸盐、总蛋白和淀粉酶活性的浓度。未观察到儿茶酚胺的血浆和尿基础水平存在差异。站立后，特应性儿童的血浆去甲肾上腺素升高幅度大于正常健康儿童。在所研究的唾液因素中，腮腺流速、碳酸氢盐、氯化物和无机磷酸盐未发现差异。特应性皮炎患儿的蛋白质浓度以及淀粉酶活性显著降低。这些发现表明，在特应性皮炎中，β-交感神经介导的反应受损；另一方面，副交感神经介导的反应保持完好。
