Peng Lujian, Liu Xiangde, Lu Qian, Tang Tengqian, Yang Zhanyu
Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China (mainland).
Med Sci Monit. 2015 May 1;21:1249-55. doi: 10.12659/MSM.893792.
Some epidemiological studies have suggested that vitamin E intake reduces the risk of pancreatic cancer; however, this conclusion has not been supported by all the published studies. We conducted a meta-analysis to assess the relationship between vitamin E intake and the risk of pancreatic cancer by combining the results from published articles.
MATERIAL/METHODS: We searched the published studies that reported the relationship between vitamin E intake and pancreatic cancer risk using the PubMed, Web of Science, and Embase databases through December 31st, 2014. Based on a fixed-effects or random-effects model, the RR and 95% CI were used to assess the combined risk.
In total, 10 observational studies (6 case-control studies and 4 cohort studies) were included. The overall RR (95% CI) of pancreatic cancer for the highest vs. the lowest level of vitamin E intake was 0.81 (0.73, 0.89). We found little evidence of heterogeneity (I2=19.8%, P=0.255). In the subgroup analyses, we found an inverse association between vitamin E intake and pancreatic cancer risk both in the case-control and cohort studies. Additionally, this inverse association was not modified by different populations.
In our meta-analysis, there was an inverse association between vitamin E intake and the risk of pancreatic cancer. A high level of vitamin E might be a protective factor for populations at risk for pancreatic cancer.
一些流行病学研究表明，摄入维生素E可降低患胰腺癌的风险；然而，这一结论并未得到所有已发表研究的支持。我们进行了一项荟萃分析，通过合并已发表文章的结果来评估维生素E摄入量与患胰腺癌风险之间的关系。
材料/方法：我们检索了截至2014年12月31日在PubMed、科学网和Embase数据库中发表的报告维生素E摄入量与胰腺癌风险关系的研究。基于固定效应或随机效应模型，使用RR和95%CI来评估合并风险。
总共纳入了10项观察性研究（6项病例对照研究和4项队列研究）。维生素E摄入量最高组与最低组相比，胰腺癌的总体RR（95%CI）为0.81（0.73，0.89）。我们几乎没有发现异质性的证据（I2=19.8%，P=0.255）。在亚组分析中，我们发现病例对照研究和队列研究中维生素E摄入量与胰腺癌风险之间均存在负相关。此外，不同人群并未改变这种负相关关系。
在我们的荟萃分析中，维生素E摄入量与胰腺癌风险之间存在负相关。高水平的维生素E可能是胰腺癌高危人群的一个保护因素。
