丝氨酸-苏氨酸蛋白磷酸酶：在翻译中迷失。
Serine-threonine protein phosphatases: Lost in translation.
机构信息
NYU College of Dentistry, Department of Basic Science and Craniofacial Biology, 345 E 24th St, New York, NY 10010, United States of America.
出版信息
Biochim Biophys Acta Mol Cell Res. 2019 Jan;1866(1):83-89. doi: 10.1016/j.bbamcr.2018.08.006. Epub 2018 Aug 20.
Abstract
Protein synthesis is one of the most complex and energy-consuming processes in eukaryotic cells and therefore is tightly regulated. One of the main mechanisms of translational control is post-translational modifications of the components of translational apparatus. Phosphorylation status of translation factors depends on the balanced action of kinases and phosphatases. While many kinase-dependent events are well defined, phosphatases that counteract phosphorylation are rarely determined. This mini-review focuses on the regulation of activity of translational initiation factors by serine/threonine phosphatases.
摘要
蛋白质合成是真核细胞中最复杂和耗能的过程之一，因此受到严格的调控。翻译调控的主要机制之一是翻译装置成分的翻译后修饰。翻译因子的磷酸化状态取决于激酶和磷酸酶的平衡作用。虽然许多依赖激酶的事件已经得到很好的定义，但很少确定对抗磷酸化的磷酸酶。本篇综述聚焦于丝氨酸/苏氨酸磷酸酶对翻译起始因子活性的调节。
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