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老年人烧伤后的神经认知后遗症。

Neurocognitive sequela of burn injury in the elderly.

作者信息

Esechie Aimalohi, Bhardwaj Anish, Masel Todd, Raji Mukaila

机构信息

Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.

Department of Neurology, University of Texas Medical Branch, Galveston, TX, United States.

出版信息

J Clin Neurosci. 2019 Jan;59:1-5. doi: 10.1016/j.jocn.2018.10.089. Epub 2018 Nov 3.

DOI:10.1016/j.jocn.2018.10.089
PMID:30401568
Abstract

Elderly individuals are a fast-rising segment of the US population and are at high risk of permanent disability and premature death secondary to traumatic injuries such as burn injury. The current paper will review the extant literature to understand the prevalence of burn injury in the elderly, the neurocognitive complications unique to the aged that places this cohort at risk, and evidence-based recommendations to reduce the early and late neurocognitive effects of burn injury in the aged. The elderly are a high-risk population for burn injury and its neurological sequela. This risk, at least in part, reflects multiple factors: age-related changes in the central and peripheral nervous system; multiple pre-existing co-morbidities (such as dementia and COPD); polypharmacy; suboptimal social support; and increased susceptibility to hypothermia, burn-related infections, and electrolyte and metabolic dysregulations.

摘要

老年人是美国人口中快速增长的一部分,因烧伤等创伤性损伤而面临永久性残疾和过早死亡的高风险。本文将回顾现有文献,以了解老年人烧伤的患病率、该年龄段特有的使其面临风险的神经认知并发症,以及减少老年人烧伤早期和晚期神经认知影响的循证建议。老年人是烧伤及其神经后遗症的高危人群。这种风险至少部分反映了多种因素:中枢和周围神经系统的年龄相关变化;多种预先存在的合并症(如痴呆和慢性阻塞性肺疾病);多种药物治疗;社会支持不足;以及对体温过低、烧伤相关感染、电解质和代谢失调的易感性增加。

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Neurocognitive sequela of burn injury in the elderly.老年人烧伤后的神经认知后遗症。
J Clin Neurosci. 2019 Jan;59:1-5. doi: 10.1016/j.jocn.2018.10.089. Epub 2018 Nov 3.
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Dementia: A risk factor for burns in the elderly.痴呆症:老年人烧伤的一个风险因素。
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BMC Geriatr. 2023 Oct 19;23(1):680. doi: 10.1186/s12877-023-04302-5.
2
[Research advances on post-burn cognitive disorders and its mechanism].烧伤后认知障碍及其机制的研究进展
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Aug 20;39(8):790-794. doi: 10.3760/cma.j.cn501225-20221117-00492.
3
A systematic review assessing the effectiveness of hand therapy programmes in adults with burns using the International Classification of Functioning, Disability and Health framework.
采用国际功能、残疾和健康分类框架评估手部治疗方案对烧伤成人的有效性的系统评价。
Nagoya J Med Sci. 2022 Nov;84(4):689-704. doi: 10.18999/nagjms.84.4.689.
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Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice.皮肤烧伤损伤可诱导老年小鼠海马中的神经炎症和反应性星形胶质细胞激活。
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Abnormal Dorsal Caudate Activation Mediated Impaired Cognitive Flexibility in Mild Traumatic Brain Injury.背侧尾状核激活异常介导轻度创伤性脑损伤患者认知灵活性受损。
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