Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, NC 27157, U.S.A.
Centers for Genomics and Personalized Medicine Research and Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, U.S.A.
Clin Sci (Lond). 2018 Dec 5;132(23):2509-2518. doi: 10.1042/CS20180690. Print 2018 Dec 12.
Blood-based bioenergetic profiling has promising applications as a minimally invasive biomarker of systemic bioenergetic capacity. In the present study, we examined peripheral blood mononuclear cell (PBMC) mitochondrial function and brain morphology in a cohort of African Americans with long-standing Type 2 diabetes. Key parameters of PBMC respiration were correlated with white matter, gray matter, and total intracranial volumes. Our analyses indicate that these relationships are primarily driven by the relationship of systemic bioenergetic capacity with total intracranial volume, suggesting that systemic differences in mitochondrial function may play a role in overall brain morphology.
基于血液的生物能量谱分析作为一种系统生物能量能力的微创生物标志物具有广阔的应用前景。在本研究中，我们研究了患有长期 2 型糖尿病的非裔美国人的外周血单个核细胞 (PBMC) 线粒体功能和大脑形态。PBMC 呼吸的关键参数与白质、灰质和总颅内体积相关。我们的分析表明，这些关系主要是由全身生物能量能力与总颅内体积的关系驱动的，这表明线粒体功能的全身差异可能在整体大脑形态中起作用。
