Rodriguez del Castillo A, Battaner E, Guerra M, Alonso T, Mas M
Brain Res. 1987 Jul 21;416(1):113-8. doi: 10.1016/0006-8993(87)91502-2.
Synaptosomal Na+,K+-transporting ATPase activity of the mediobasal hypothalamus (MBH), the medial preoptic-suprachiasmatic (POSC) region and cerebral cortex was measured in rats at different stages of the estrous cycle and after ovariectomy and estradiol replacement. Enzyme activity of the MBH and POSC showed cyclic changes. In both regions it increased shortly before the proestrus surge of LH. However, the two areas responded to castration and estrogen treatment in an opposite fashion. No changes were detected in enzyme activity in the cerebral cortex. These findings are consistent with previous reports on cyclic changes in electrical activity and suggest that Na+,K+-ATPase activity could be a useful indicator of neural activity for the study of neuroendocrine interactions.
在动情周期的不同阶段、卵巢切除术后以及雌二醇替代后，测量了大鼠下丘脑中间基底部（MBH）、内侧视前 - 视交叉上核（POSC）区域和大脑皮层的突触体钠钾转运ATP酶活性。MBH和POSC的酶活性呈现周期性变化。在这两个区域，其活性在促黄体生成素（LH）发情前期激增前不久升高。然而，这两个区域对去势和雌激素治疗的反应相反。大脑皮层的酶活性未检测到变化。这些发现与先前关于电活动周期性变化的报道一致，并表明钠钾ATP酶活性可能是研究神经内分泌相互作用时神经活动的一个有用指标。
