Zhang Junyi, He Shuai, Li Yunchuan, Lv Minggang, Wei Hongzheng, Qu Bin, Zheng Yani, Hu Chunhua
Department of Otolaryngology, Harbin First Hospital, Harbin, Heilongjiang 150070, P.R. China.
Department of Otolaryngology, Daqing Oilfield General Hospital, Daqing, Heilongjiang 163001, P.R. China.
Exp Ther Med. 2018 Nov;16(5):4207-4212. doi: 10.3892/etm.2018.6726. Epub 2018 Sep 11.
Identifying the predominant microbial species in patients with ethmoidal sinusitis is conducive to its successful treatment. The aim of the present study was to determine the microbial composition and the predominant fungal and bacterial species in patients with ethmoidal sinusitis. A sample was obtained from 3 patients with ethmoidal sinusitis and from the ethmoid sinus of 2 healthy volunteers. Those samples were sequenced using an Illumina/Solexa sequencing platform for mapping to human, fungal, and bacterial genomes. Fungal and bacterial expressions in those samples were analyzed through bioinformatics and statistical methods. The sequencing data revealed that the dominant fungal strains in the ethmoidal sinusitis samples compared with the healthy controls (8_S33 and 10_S9) were and , and the dominant bacterial strains were and . Together, these findings indicate that the development of ethmoidal sinusitis is associated with the presence of fungi and bacteria, which may benefit the successful diagnosis and treatment for patients with ethmoidal sinusitis.
确定筛窦炎患者中的主要微生物种类有助于其成功治疗。本研究的目的是确定筛窦炎患者的微生物组成以及主要的真菌和细菌种类。从3例筛窦炎患者和2名健康志愿者的筛窦中获取样本。使用Illumina/Solexa测序平台对这些样本进行测序，以映射到人类、真菌和细菌基因组。通过生物信息学和统计方法分析这些样本中的真菌和细菌表达。测序数据显示，与健康对照（8_S33和10_S9）相比，筛窦炎样本中的优势真菌菌株为 和 ，优势细菌菌株为 和 。总之，这些发现表明筛窦炎的发生与真菌和细菌的存在有关，这可能有助于筛窦炎患者的成功诊断和治疗。
