Alabiad Mohamed Ali, Harb Ola A, Taha Heba F, El Shafaay Basant Sh, Gertallah Loay M, Salama Nashaat
Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Pathol Oncol Res. 2019 Apr;25(2):611-624. doi: 10.1007/s12253-018-0534-1. Epub 2018 Nov 6.
The initiation of prostatic malignancy has been linked to chronic inflammation. Stem cell factor (SCF) is an inflammatory cytokine that is specific to the c-KIT receptor which is type III receptor tyrosine kinase (RTK). Cyclooxygenases (COXs) are the main enzymes which are responsible for prostaglandins production from arachidonic acid. COX2 is an enzyme which is produced under different pathological conditions. The aim of our study; is to investigate the clinicopathological and the prognostic significance of SCF and COX-2 expression in prostatic adenocarcinoma (PC), chronic prostatitis and nodular prostatic hyperplasia (NPH) in a trial to clarify the role of inflammation as a risk factor for prostatic carcinogenesis and cancer progression. SCF and COX-2 tissue protein expression were evaluated in 50 cases of PC, 20 cases of chronic prostatitis and 10 cases of NPH using immunohistochemistry, patients were followed up for 5 years. The relationship between their levels of expressions, clinicopathological, and prognostic criteria were studied. SCF expression in PC was positively correlated with advanced patient age (p = <0.001), high level of PSA (p = 0.010), higher Gleason score (p = 0.011). COX-2 expression in PC was positively correlated with advanced patient age (p = <0.001), high level of PSA (p = 0.016), advanced D'Amico risk group (p = 0.038). High levels of expression of both SCF& COX-2 are associated with higher incidence of tumor relapse, worse disease overall survival and free survival (p < 0.001). SCF and COX-2 are associated with PC progression and associated with poor prognosis in PC patients.
前列腺恶性肿瘤的发生与慢性炎症有关。干细胞因子（SCF）是一种炎症细胞因子，它特异性作用于III型受体酪氨酸激酶（RTK）的c-KIT受体。环氧化酶（COXs）是负责将花生四烯酸转化为前列腺素的主要酶。COX2是在不同病理条件下产生的一种酶。我们研究的目的是，通过一项试验来调查SCF和COX-2在前列腺腺癌（PC）、慢性前列腺炎和前列腺结节性增生（NPH）中的临床病理及预后意义，以阐明炎症作为前列腺癌发生和癌症进展风险因素的作用。使用免疫组织化学方法评估了50例PC、20例慢性前列腺炎和10例NPH患者的SCF和COX-2组织蛋白表达情况，并对患者进行了5年的随访。研究了它们的表达水平、临床病理和预后标准之间的关系。PC中SCF的表达与患者高龄（p = <0.001）、高水平的前列腺特异性抗原（PSA）（p = 0.010）、较高的Gleason评分（p = 0.011）呈正相关。PC中COX-2的表达与患者高龄（p = <0.001）、高水平的PSA（p = 0.016）、晚期D'Amico风险组（p = 0.038）呈正相关。SCF和COX-2的高表达水平与肿瘤复发的高发生率、更差的疾病总生存率和无病生存率相关（p < 0.001）。SCF和COX-2与PC进展相关，且与PC患者的不良预后相关。
