微流控自体血清眼药水制备作为一种潜在的干眼症治疗方法。

Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment.

作者信息

Yasui Takao, Morikawa Jumpei, Kaji Noritada, Tokeshi Manabu, Tsubota Kazuo, Baba Yoshinobu

机构信息

Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.

ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.

出版信息

Micromachines (Basel). 2016 Jul 4;7(7):113. doi: 10.3390/mi7070113.

DOI:10.3390/mi7070113

PMID:30404287

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6189724/

Abstract

Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.

摘要

干眼症是泪液质量和/或数量方面的问题，全球有数百万人受其困扰。自体血清滴眼液是治疗干眼症的理想选择；然而，滴眼液的制备过程耗时较长且相对麻烦。在此，我们利用螺旋微通道展示了一种制备自体血清滴眼液的策略，这对所有干眼症患者都有益处；对于10μm的微珠和全血细胞，去除效率分别达到了100%和90%。由于我们的策略允许研究人员将其他功能微通道集成到一个设备中，这样的微流控设备将能够提供一种用于自体血清滴眼液的新型一步制备系统。